The Neo-Paradigm has opened and an army of alien criminals have been released, and the alliance the Doctor made with the Daleks, Judoon, Sontarans, Cybermen and Atraxi has been broken. This may prove to be the Doctor's toughest challenge yet. Earth has vanished, along with the rest of humanity. Amy is still lost and Karlel has mysteriously reappeared, inside the Pandorica. Can the Doctor stop the Neo-Paradigm from destroying the universe? It could prove to be his toughest challenge yet, especially now the TARDIS has disappeared.